The Second Best Hospital in the Galaxy Season 2 OTT Release Date: When and where to watch Cirocco Dunlap’s show

The Second Best Hospital in the Galaxy S2 OTT Release Date: Two alien doctors tackle bizarre space illnesses while uncovering secrets from their past. The sci-fi comedy returns with more wild adventures.

Aditya SagarUpdated: May 20, 2025, 13:53 IST
2 min read
The Second Best Hospital in the Galaxy Season 2
A still from The Second Best Hospital in the Galaxy Season 2 | Credits: Prime

The Second Best Hospital in the Galaxy Season 2 OTT Release Date: This animated sci-fi comedy series returns with its second season on Tuesday, May 27, 2025, exclusively on Amazon Prime Video. All eight episodes will be available for streaming on the release day. Here’s everything you need to know!

Plot overview

Created by Cirocco Dunlap, known for her work on Russian Doll and Baymax!, The Second Best Hospital in the Galaxy follows two alien surgeons, Dr. Sleech (voiced by Stephanie Hsu) and Dr. Klak (voiced by Keke Palmer), as they navigate bizarre medical cases in a space hospital. The voice cast also includes Natasha Lyonne, Maya Rudolph, Kieran Culkin, and Sam Smith.

The Second Best Hospital in the Galaxy Season 1 recap

In Season 1, Dr. Sleech and Dr. Klak tackled a variety of unusual medical cases, such as anxiety-eating parasites and patients trapped in time loops. The season also explored the personal lives of the doctors, including Dr. Klak's struggle with anxiety and Dr. Sleech's mysterious past.

What to expect in Season 2?

The Second Best Hospital in the Galaxy Season 2 explores more into Dr. Sleech's backstory as a persistent cyborg journalist investigates her past, uncovering controversial incidents. Viewers can expect more outlandish medical scenarios, including alien parasites, ailing hybrid creatures, and the controversial prospect of a new mind control therapy.

The show will mark return of Stephanie Hsu as Dr. Sleech, Keke Palmer as Dr. Klak, Kieran Culkin as Dr. Plowp, Natasha Lyonne as Nurse Tup, Maya Rudolph as Dr. Vlam, Sam Smith as Dr. Azel, Andrew Dismukes, Gary Anthony Williams, Lennon Parham, and guest stars like Tracee Ellis Ross, Bowen Yang, and Abbi Jacobson also lend their voices to various characters.

The Second Best Hospital in the Galaxy is produced by Amazon MGM Studios, Animal Pictures, and Titmouse, Inc., with Cirocco Dunlap serving as the showrunner.

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First Published: May 20, 2025, 13:52 IST
Aditya Sagar - Author

Aditya Sagar is a journalist at Indiatimes who pulls the strings on what’s hot and what hits headlines. With entertainment in one hand and the internet’s pulse in the other, he crafts stories that ripple through pop culture. Want to know what’s next? Follow @theadityasagar - he already knows!

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